BDBM50148076 17-cyclopropylmethyl-3-hydroxy-10-(3-phenylpropoxy)-(1R,9R,10S)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-one::CHEMBL325347

SMILES Oc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OCCCc3ccccc3)c12

InChI Key InChIKey=IWZLUXJMEHSPFL-UHFFFAOYSA-N

Data  3 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50148076   

TargetMu-type opioid receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148076(17-cyclopropylmethyl-3-hydroxy-10-(3-phenylpropoxy...)
Affinity DataEC50:  3.5nMAssay Description:Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human Opioid receptor mu 1 expre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148076(17-cyclopropylmethyl-3-hydroxy-10-(3-phenylpropoxy...)
Affinity DataEC50:  4.5nMAssay Description:Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human Opioid receptor kappa 1 ex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148076(17-cyclopropylmethyl-3-hydroxy-10-(3-phenylpropoxy...)
Affinity DataEC50:  7.90nMAssay Description:Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human opioid receptor delta 1 ex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148076(17-cyclopropylmethyl-3-hydroxy-10-(3-phenylpropoxy...)
Affinity DataKi:  400nMAssay Description:Binding affinity determined by displacing [3H]DAMGO from Opioid receptor mu 1 in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148076(17-cyclopropylmethyl-3-hydroxy-10-(3-phenylpropoxy...)
Affinity DataKi:  5.06E+3nMAssay Description:Binding affinity determined by displacing [3H][Ile5,6]deltorphin II from opioid receptor delta 1 in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148076(17-cyclopropylmethyl-3-hydroxy-10-(3-phenylpropoxy...)
Affinity DataKi:  5.84E+3nMAssay Description:Binding affinity determined by displacing [3H]U69,593 from Opioid receptor kappa 1 in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed