BDBM50148164 4-(4-Methoxy-pyridin-2-ylamino)-piperidine-1-carboxylic acid ethyl ester::CHEMBL112246::Ethyl 4-[(4-methoxypyridin-2-yl)amino]piperidine-1-carboxylate, 11::ethyl 4-(4-methoxypyridin-2-ylamino)piperidine-1-carboxylate

SMILES CCOC(=O)N1CCC(CC1)Nc1cc(OC)ccn1

InChI Key InChIKey=GCTVYNAQYNTXBH-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50148164   

TargetNitric oxide synthase, inducible(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148164(Ethyl 4-[(4-methoxypyridin-2-yl)amino]piperidine-1...)
Affinity DataIC50: 89nMAssay Description:Inhibition of iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148164(Ethyl 4-[(4-methoxypyridin-2-yl)amino]piperidine-1...)
Affinity DataIC50: 89nMAssay Description:In vitro inhibition of human Inducible nitric oxide synthase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50148164(Ethyl 4-[(4-methoxypyridin-2-yl)amino]piperidine-1...)
Affinity DataIC50: 90nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
The Scripps Research Institute

LigandPNGBDBM50148164(Ethyl 4-[(4-methoxypyridin-2-yl)amino]piperidine-1...)
Affinity DataIC50: 3.00E+4nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
The Scripps Research Institute

LigandPNGBDBM50148164(Ethyl 4-[(4-methoxypyridin-2-yl)amino]piperidine-1...)
Affinity DataIC50: 3.20E+4nMAssay Description:In vitro inhibition of human neuronal nitric oxide synthase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50148164(Ethyl 4-[(4-methoxypyridin-2-yl)amino]piperidine-1...)
Affinity DataIC50: 4.10E+4nMAssay Description:In vitro inhibition of human endothelial nitric oxide synthase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50148164(Ethyl 4-[(4-methoxypyridin-2-yl)amino]piperidine-1...)
Affinity DataIC50: 1.00E+5nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2011
Entry Details Article
PubMed