BDBM50149672 CHEMBL184850::[3-(5-Dimethylamino-3-methyl-pyridin-2-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-dipropyl-amine

SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(cc1C)N(C)C

InChI Key InChIKey=AVIYBZJGACSQAF-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50149672   

TargetCorticotropin-releasing factor receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50149672([3-(5-Dimethylamino-3-methyl-pyridin-2-yl)-2,5-dim...)
Affinity DataKi:  10nMAssay Description:Binding affinity for recombinant human CRF1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50149672([3-(5-Dimethylamino-3-methyl-pyridin-2-yl)-2,5-dim...)
Affinity DataKi:  10nMAssay Description:Inhibition of [125I]o-CRF binding to CHO cells expressing human CRF1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50149672([3-(5-Dimethylamino-3-methyl-pyridin-2-yl)-2,5-dim...)
Affinity DataIC50: 150nMAssay Description:Inhibition of CRF-stimulated cAMP production in cells expressing CRF1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50149672([3-(5-Dimethylamino-3-methyl-pyridin-2-yl)-2,5-dim...)
Affinity DataIC50: 160nMAssay Description:Inhibition of [125I]o-CRF binding to CHO cells expressing human CRF1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed