BDBM50150246 1-Acetyl-4-(4-but-2-ynyloxy-benzenesulfonyl)-8-hydroxymethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-3-carboxylic acid hydroxyamide::1-acetyl-4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydroxy-8-(hydroxymethyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-3-carboxamide::CHEMBL183924

SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N1Cc2ccc(CO)cc2N(CC1C(=O)NO)C(C)=O

InChI Key InChIKey=JQGYJNKTRDAQCV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50150246   

TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150246(1-acetyl-4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hyd...)
Affinity DataIC50: 500nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150246(1-acetyl-4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hyd...)
Affinity DataIC50: 20nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50150246(1-acetyl-4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hyd...)
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50150246(1-acetyl-4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hyd...)
Affinity DataIC50: 12nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150246(1-acetyl-4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hyd...)
Affinity DataIC50: 20nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed