BDBM50150473 CHEMBL3769671

SMILES Cc1cn(cn1)-c1ccc2Nc3nc(Cc4ccccc4)sc3CCc2c1

InChI Key InChIKey=ZHNDWSFRNPTACV-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50150473   

TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL

LigandBDBM50150473(CHEMBL3769671)Copy SMILESCopy InChI

Affinity DataIC50: 35nMAssay Description:Modulation of gamma secretase in human H4 cells assessed as inhibition of amyloid beta (1 to 42) productionMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
6/26/2017
Entry Details Article
Copy BDB DOIPubMed
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TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL

LigandBDBM50150473(CHEMBL3769671)Copy SMILESCopy InChI

Affinity DataIC50: 700nMAssay Description:Inhibition of CYP3A4 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
6/26/2017
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL