BDBM50150776 (3-Chloro-4-fluoro-phenyl)-(5-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-yl)-amine::CHEMBL188304::N-(3-chloro-4-fluorophenyl)-5-methylpyrrolo[1,2-f][1,2,4]triazin-4-amine

SMILES Cc1ccn2ncnc(Nc3ccc(F)c(Cl)c3)c12

InChI Key InChIKey=MQUDAGONIFHBJH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50150776   

TargetEpidermal growth factor receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150776(N-(3-chloro-4-fluorophenyl)-5-methylpyrrolo[1,2-f]...)
Affinity DataIC50: 100nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Universita Degli Studi Di Palermo

Curated by ChEMBL
LigandPNGBDBM50150776(N-(3-chloro-4-fluorophenyl)-5-methylpyrrolo[1,2-f]...)
Affinity DataIC50: 100nMAssay Description:Inhibition of VEGFR-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150776(N-(3-chloro-4-fluorophenyl)-5-methylpyrrolo[1,2-f]...)
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150776(N-(3-chloro-4-fluorophenyl)-5-methylpyrrolo[1,2-f]...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant cytoplasmic HER2 kinase expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Universita Degli Studi Di Palermo

Curated by ChEMBL
LigandPNGBDBM50150776(N-(3-chloro-4-fluorophenyl)-5-methylpyrrolo[1,2-f]...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150776(N-(3-chloro-4-fluorophenyl)-5-methylpyrrolo[1,2-f]...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed