BDBM50151598 1N-(2-dimethylaminoethyl)-4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',2'',3'',4''-tetrahydroquinazoline)]-6-yl]benzamide::CHEMBL366149

SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1

InChI Key InChIKey=JSHWMJVMONRVOW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50151598   

LigandPNGBDBM50151598(1N-(2-dimethylaminoethyl)-4-[8''-chloro-2''-oxospi...)
Affinity DataIC50: 20nMAssay Description:In vitro inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50151598(1N-(2-dimethylaminoethyl)-4-[8''-chloro-2''-oxospi...)
Affinity DataIC50: 1.63E+3nMAssay Description:In vitro inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50151598(1N-(2-dimethylaminoethyl)-4-[8''-chloro-2''-oxospi...)
Affinity DataIC50: 6.29E+3nMAssay Description:In vitro inhibition of human Phosphodiesterase 1 partially purified from THP-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50151598(1N-(2-dimethylaminoethyl)-4-[8''-chloro-2''-oxospi...)
Affinity DataIC50: 4.22E+4nMAssay Description:In vitro inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50151598(1N-(2-dimethylaminoethyl)-4-[8''-chloro-2''-oxospi...)
Affinity DataIC50: 6.73E+4nMAssay Description:In vitro inhibition of human Phosphodiesterase 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed