BDBM50151663 CHEMBL3774655

SMILES CCC(=O)N1CCOc2c(C1)cc(cc2OC[C@H]1CCCN(C)C1)-c1ccc(OC)c(OC)c1

InChI Key InChIKey=YKNAKDFZAWQEEO-UHFFFAOYSA-N

Data  6 IC50  5 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50151663   

TargetCREB-binding protein(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151663(CHEMBL3774655)
Affinity DataKd:  151nMAssay Description:Inhibition of human CREBBP expressed in competent escherichia coli BL21(DE3)-R3-pRARE2 cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2017
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151663(CHEMBL3774655)
Affinity DataKd:  167nMAssay Description:Inhibition of human p300 expressed in competent escherichia coli BL21(DE3)-R3-pRARE2 cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2017
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151663(CHEMBL3774655)
Affinity DataIC50: 170nMAssay Description:Inhibition of CBP (unknown origin) by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151663(CHEMBL3774655)
Affinity DataKd:  151nMAssay Description:Binding affinity to CBP (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50151663(CHEMBL3774655)
Affinity DataIC50: 1.50E+4nMAssay Description:Displacement of biotinylated ligand from BRD4 bromodomain-1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMed
TargetCREB-binding protein/Histone acetyltransferase p300(Human)
Ludwig-Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50151663(CHEMBL3774655)
Affinity DataKd:  151nMAssay Description:Binding affinity to human CBP/P300 expressed in Escherichia coli BL21(DE3)-R3 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2018
Entry Details Article
PubMed
TargetCREB-binding protein/Histone acetyltransferase p300(Human)
Ludwig-Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50151663(CHEMBL3774655)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of CBP/EP300 (unknown origin) assessed as reduction in MYC expression by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151663(CHEMBL3774655)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Halo-tagged histone H3.3 binding to NanoLuc luciferase conjugated CBP (unknown origin) expressed in HEK293 cells after overnight incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151663(CHEMBL3774655)
Affinity DataIC50: 440nMAssay Description:Displacement of biotinylated ligand from CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50151663(CHEMBL3774655)
Affinity DataIC50: 440nMAssay Description:Inhibition of His tagged recombinant CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50151663(CHEMBL3774655)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of His tagged recombinant BRD4 bromodomain 1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50151663(CHEMBL3774655)
Affinity DataKd:  5.60E+3nMAssay Description:Binding affinity to human BRD4 BD1 (N44 to E168 aa residues) by bromoKdELECT Discover assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed