BDBM50152010 3-{4-[4-(3-Cyano-4-hydroxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrile::CHEMBL363754

SMILES Oc1ccc(cc1C#N)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1

InChI Key InChIKey=VUPDCEKJOFIAMS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50152010   

LigandPNGBDBM50152010(3-{4-[4-(3-Cyano-4-hydroxy-phenyl)-piperazin-1-yl]...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of [3H]5-HT re-uptake in rat synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50152010(3-{4-[4-(3-Cyano-4-hydroxy-phenyl)-piperazin-1-yl]...)
Affinity DataIC50: 43nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor of rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50152010(3-{4-[4-(3-Cyano-4-hydroxy-phenyl)-piperazin-1-yl]...)
Affinity DataIC50: 400nMAssay Description:Inhibition of 8-OH DPAT binding to rat hydroxytryptamine 1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed