BDBM50154892 CHEMBL3775967::US10273244, Example 27::US10584135, Example 27

SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCN(C3C2)c2c(F)cccc2F)n1C

InChI Key InChIKey=YZMAJSYJKLQFNB-UHFFFAOYSA-N

Data  6 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50154892   

TargetD(3) dopamine receptor(Human)
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154892(CHEMBL3775967 | US10273244, Example 27 | US1058413...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2017
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154892(CHEMBL3775967 | US10273244, Example 27 | US1058413...)
Affinity DataKi:  2.63nMAssay Description:3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154892(CHEMBL3775967 | US10273244, Example 27 | US1058413...)
Affinity DataKi:  2.63nMAssay Description:[3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154892(CHEMBL3775967 | US10273244, Example 27 | US1058413...)
Affinity DataKi:  501nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes after 120 mins by liquid scintillation counter meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2017
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154892(CHEMBL3775967 | US10273244, Example 27 | US1058413...)
Affinity DataKi:  501nMAssay Description:Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
Aptuit

Curated by ChEMBL
LigandPNGBDBM50154892(CHEMBL3775967 | US10273244, Example 27 | US1058413...)
Affinity DataKi:  501nMAssay Description:CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were re-suspended ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

LigandPNGBDBM50154892(CHEMBL3775967 | US10273244, Example 27 | US1058413...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2017
Entry Details Article
PubMed