BDBM50154972 CHEMBL366333::[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-phenyl]-pyridin-3-yl-amine

SMILES Fc1cc(Nc2cccnc2)cc(c1)-n1nnc(n1)-c1ccccn1

InChI Key InChIKey=KSMWUJIVIRLPNY-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50154972   

TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50154972([3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-phenyl]...)
Affinity DataKi:  29nMAssay Description:Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50154972([3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-phenyl]...)
Affinity DataIC50: 124nMAssay Description:Antagonistic activity against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed