BDBM50155210 CHEMBL426972::N-(5-Isopropyl-thiazol-2-yl)-2-phenyl-acetamide

SMILES CC(C)c1cnc(NC(=O)Cc2ccccc2)s1

InChI Key InChIKey=IGRZXNLKVUEFDM-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50155210   

TargetCyclin-dependent kinase 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50155210(N-(5-Isopropyl-thiazol-2-yl)-2-phenyl-acetamide | ...)
Affinity DataIC50: 64nMAssay Description:Concentration required for inhibition of cyclin-dependent kinase 5 was measured by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50155210(N-(5-Isopropyl-thiazol-2-yl)-2-phenyl-acetamide | ...)
Affinity DataIC50: 98nMAssay Description:Concentration required for 50% inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50155210(N-(5-Isopropyl-thiazol-2-yl)-2-phenyl-acetamide | ...)
Affinity DataIC50: 195nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50155210(N-(5-Isopropyl-thiazol-2-yl)-2-phenyl-acetamide | ...)
Affinity DataIC50: 353nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50155210(N-(5-Isopropyl-thiazol-2-yl)-2-phenyl-acetamide | ...)
Affinity DataIC50: 458nMAssay Description:Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50155210(N-(5-Isopropyl-thiazol-2-yl)-2-phenyl-acetamide | ...)
Affinity DataIC50: 637nMAssay Description:Inhibition of GST-tagged CDK7/cyclinH/MAT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50155210(N-(5-Isopropyl-thiazol-2-yl)-2-phenyl-acetamide | ...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50155210(N-(5-Isopropyl-thiazol-2-yl)-2-phenyl-acetamide | ...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50155210(N-(5-Isopropyl-thiazol-2-yl)-2-phenyl-acetamide | ...)
Affinity DataIC50: 2.04E+4nMAssay Description:Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed