BDBM50156457 CHEMBL186730::[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[3-(3-thiophen-2-yl-[1,2,4]oxadiazol-5-yl)-phenyl]-methanone

SMILES NCc1ccc(F)c(c1)C1CCN(CC1)C(=O)c1cccc(c1)-c1nc(no1)-c1cccs1

InChI Key InChIKey=YFBRXKLPGVWRRC-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50156457   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156457([4-(5-Aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]...)
Affinity DataIC50: 800nMAssay Description:Inhibitory activity against human Potassium channel HERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156457([4-(5-Aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]...)
Affinity DataIC50: 480nMAssay Description:Inhibitory activity against cytochrome P450 determined using human liver microsome upon 15 min incubation with probes substrates Tolbutamide (2C9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156457([4-(5-Aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]...)
Affinity DataIC50: 2.19E+3nMAssay Description:Inhibitory activity against cytochrome P450 determined using human liver microsome upon 15 min incubation with probes substrates s-mephenytoin (2C19)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156457([4-(5-Aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]...)
Affinity DataKi:  4.30nMAssay Description:Inhibitory activity against human mast cell tryptase betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed