BDBM50156589 1-(4-chlorophenyl)-3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)phenoxymethyl]-5-phenyl-1H-pyrazole::CHEMBL222146

SMILES COC1(CCOCC1)c1cc(F)cc(OCc2cc(-c3ccccc3)n(n2)-c2ccc(Cl)cc2)c1

InChI Key InChIKey=ITXUVIRIRIWMQU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50156589   

TargetProstaglandin G/H synthase 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50156589(1-(4-chlorophenyl)-3-[3-fluoro-5-(4-methoxytetrahy...)
Affinity DataIC50: 1.81E+3nMAssay Description:Inhibition of COX1 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50156589(1-(4-chlorophenyl)-3-[3-fluoro-5-(4-methoxytetrahy...)
Affinity DataIC50: 930nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50156589(1-(4-chlorophenyl)-3-[3-fluoro-5-(4-methoxytetrahy...)
Affinity DataIC50: 830nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed