BDBM50158355 CHEMBL3781822::US10858316, Compound 3bl

SMILES Cc1cc(Oc2ccc(cc2)N(Cc2ccccc2)S(=O)(=O)c2cc(C(O)=O)c(O)c3ccccc23)cc(C)c1Cl

InChI Key InChIKey=QWMLIWOCYWXRDD-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50158355   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50158355(CHEMBL3781822 | US10858316, Compound 3bl)
Affinity DataKi:  31nMAssay Description:Inhibition of His6-MBP tagged recombinant human Mcl-1 residues 172 to 327 expressed in Escherichia coli assessed as inhibition of interaction with Ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50158355(CHEMBL3781822 | US10858316, Compound 3bl)
Affinity DataKi:  31nMAssay Description:Molecular modeling and SILCS functional group affinity mapping (FragMaps) of the Mcl-1 binding site indicated that the carboxylic acid of designed mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50158355(CHEMBL3781822 | US10858316, Compound 3bl)
Affinity DataKi:  31nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50158355(CHEMBL3781822 | US10858316, Compound 3bl)
Affinity DataKi:  31nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Human)
University of Maryland, Baltimore

US Patent
LigandPNGBDBM50158355(CHEMBL3781822 | US10858316, Compound 3bl)
Affinity DataKi:  340nMAssay Description:Molecular modeling and SILCS functional group affinity mapping (FragMaps) of the Mcl-1 binding site indicated that the carboxylic acid of designed mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent