BDBM50158694 CHEMBL3786803::US10273222, Example 12

SMILES COc1ccc(cc1)-c1c(ncn1C)-c1cc(ccn1)C(O)=O

InChI Key InChIKey=XGBOARWPNSLLHZ-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50158694   

TargetLysine-specific demethylase 2B(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158694(CHEMBL3786803 | US10273222, Example 12)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged KDM2B (1 to 650 residues) expressed in baculovirus infected sf9 cells using biotin-H3K36me2 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158694(CHEMBL3786803 | US10273222, Example 12)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged KDM5A (1 to 1090 residues) expressed in baculovirus infected sf9 cells using biotin-H3K4me3 su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 5B(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158694(CHEMBL3786803 | US10273222, Example 12)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human N-terminal His-FLAG-tagged KDM5B (2 to 751 residues) expressed in baculovirus infected sf9 cells using biotin-H3K4me3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 2B(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158694(CHEMBL3786803 | US10273222, Example 12)
Affinity DataIC50: 550nMAssay Description:The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent

TargetLysine-specific demethylase 5B(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158694(CHEMBL3786803 | US10273222, Example 12)
Affinity DataIC50: 550nMAssay Description:The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent

TargetLysine-specific demethylase 5A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158694(CHEMBL3786803 | US10273222, Example 12)
Affinity DataIC50: 550nMAssay Description:The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent

TargetLysine-specific demethylase 5A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158694(CHEMBL3786803 | US10273222, Example 12)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KDM5A in human ZR-75-1 cells assessed as reduction in H3K4me3 demethylation incubated for 72 hrs by fluorometric immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 5B(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158694(CHEMBL3786803 | US10273222, Example 12)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KDM5B in human ZR-75-1 cells assessed as reduction in H3K4me3 demethylation incubated for 72 hrs by fluorometric immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4C(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158694(CHEMBL3786803 | US10273222, Example 12)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged KDM4C (2 to 372 residues) expressed in baculovirus infected sf9 cells using biotin-H3K9me3 subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4C(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158694(CHEMBL3786803 | US10273222, Example 12)
Affinity DataIC50: 5.50E+3nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent