BDBM50158830 CHEMBL3785583

SMILES CC(C)C1=C(Nc2c(cnn2C1=O)C#N)c3cnn(c3)C(C)(C)C

InChI Key InChIKey=KRXWJZIHQRIGSJ-UHFFFAOYSA-N

Data  13 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50158830   

TargetLysine-specific demethylase 5A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158830(CHEMBL3785583)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant full length FLAG-tagged KDM5A (unknown origin) expressed in sf9 cells using biotin-H3K4me3 (1 to 21 residues as substrate p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158830(CHEMBL3785583)
Affinity DataEC50:  180nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as reduction in demethylation of H3K4me3 after 120 hrs by AlphaLisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5B(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158830(CHEMBL3785583)
Affinity DataEC50:  180nMAssay Description:Inhibition of KDM5B in human PC9 cells assessed as reduction in demethylation of H3K4me3 after 120 hrs by AlphaLisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5C(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50158830(CHEMBL3785583)
Affinity DataIC50: 66nMAssay Description:Inhibition of KDM5C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5C(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50158830(CHEMBL3785583)
Affinity DataIC50: 66nMAssay Description:Inhibition of KDM5C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 4C(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50158830(CHEMBL3785583)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of KDM4C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetLysine-specific demethylase 5B(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158830(CHEMBL3785583)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158830(CHEMBL3785583)
Affinity DataIC50: 15nMAssay Description:Inhibition of KDM5A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158830(CHEMBL3785583)
Affinity DataIC50: 15nMAssay Description:Inhibition of KDM5A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 4C(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50158830(CHEMBL3785583)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of KDM4C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetLysine-specific demethylase 5B(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158830(CHEMBL3785583)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5B(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158830(CHEMBL3785583)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158830(CHEMBL3785583)
Affinity DataIC50: 15nMAssay Description:Inhibition of KDM5A (unknown origin ) by HTMS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5B(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158830(CHEMBL3785583)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of KDM5B (unknown origin ) by HTMS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5C(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50158830(CHEMBL3785583)
Affinity DataIC50: 66nMAssay Description:Inhibition of KDM5C (unknown origin ) by HTMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)