BDBM50158864 CHEMBL3785509::US10513493, Example 30

SMILES Nc1ccnc(n1)N1CCC(CC1)N[C@@H]1C[C@H]1c1ccccc1

InChI Key InChIKey=YENRXRGKFMUFQA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50158864   

TargetLysine-specific histone demethylase 1A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158864(CHEMBL3785509 | US10513493, Example 30)
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant KDM1A expressed in Escherichia coli using biotin-histone H3 as substrate preincubated for 1 hr followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158864(CHEMBL3785509 | US10513493, Example 30)
Affinity DataIC50: 100nMAssay Description:LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
US Patent