BDBM50158907 CHEMBL3786444::US11247985, Table 3.10

SMILES COc1ccc2[nH]c(cc2c1)-c1cccc(c1)N1CCC(CC1)NCCN1CCN(CC1)C(C)C

InChI Key InChIKey=LIEFKOLTZCXUOY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50158907   

TargetTransitional endoplasmic reticulum ATPase(Human)
University of Pittsburgh

US Patent
LigandPNGBDBM50158907(CHEMBL3786444 | US11247985, Table 3.10)
Affinity DataIC50: 660nMAssay Description:To optimize p97 inhibitors, the C-5 trifluoromethylated trifluoromethylated indole 12 was generated as a promising lead structure. In the ADP-Glo ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetTransitional endoplasmic reticulum ATPase(Human)
University of Pittsburgh

US Patent
LigandPNGBDBM50158907(CHEMBL3786444 | US11247985, Table 3.10)
Affinity DataIC50: 710nMAssay Description:Inhibition of wild type human AAA ATPase p97 expressed in Escherichia coli measured by ADPGlo assay in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed