BDBM50162730 4-Acetyl-1-(4-but-2-ynyloxy-benzenesulfonyl)-[1,4]diazepane-2-carboxylic acid hydroxyamide::CHEMBL180891

SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N1CCCN(CC1C(=O)NO)C(C)=O

InChI Key InChIKey=VMMAOHBHWSKMLW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50162730   

TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50162730(4-Acetyl-1-(4-but-2-ynyloxy-benzenesulfonyl)-[1,4]...)
Affinity DataIC50: 2.12E+3nMAssay Description:Inhibitory concentration against matrix metalloprotease-1 at 1 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50162730(4-Acetyl-1-(4-but-2-ynyloxy-benzenesulfonyl)-[1,4]...)
Affinity DataIC50: 305nMAssay Description:Inhibitory concentration against Matrix metalloprotease-13 at 1 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50162730(4-Acetyl-1-(4-but-2-ynyloxy-benzenesulfonyl)-[1,4]...)
Affinity DataIC50: 4nMAssay Description:Inhibitory concentration against TNF-alpha converting enzyme at 1 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50162730(4-Acetyl-1-(4-but-2-ynyloxy-benzenesulfonyl)-[1,4]...)
Affinity DataIC50: 4nMAssay Description:Inhibition of TACE (unknown origin) using fluorogenic LAQAVRSSSR peptide as a substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article