BDBM50162959 (11-Fluoro-2,3,3a,12b-tetrahydro-1-oxa-8-thia-dibenzo[e,h]azulen-2-ylmethyl)-dimethyl-amine::CHEMBL366164

SMILES CN(C)C[C@H]1C[C@H]2[C@H](O1)c1cc(F)ccc1Sc1ccccc21

InChI Key InChIKey=BSOLCASXROXPRZ-UHFFFAOYSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50162959   

TargetHistamine H1 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162959((11-Fluoro-2,3,3a,12b-tetrahydro-1-oxa-8-thia-dibe...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of [3H]pyrilamine binding to human Histamine H1 receptor More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162959((11-Fluoro-2,3,3a,12b-tetrahydro-1-oxa-8-thia-dibe...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of [3H]mesulergine binding to human 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162959((11-Fluoro-2,3,3a,12b-tetrahydro-1-oxa-8-thia-dibe...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of [125I]R91150 binding to human 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162959((11-Fluoro-2,3,3a,12b-tetrahydro-1-oxa-8-thia-dibe...)
Affinity DataKi:  6.5nMAssay Description:Inhibition of [3H]5-HT binding to human 5-hydroxytryptamine 7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162959((11-Fluoro-2,3,3a,12b-tetrahydro-1-oxa-8-thia-dibe...)
Affinity DataKi:  12nMAssay Description:Inhibition of [3H]-spiperone binding to human Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162959((11-Fluoro-2,3,3a,12b-tetrahydro-1-oxa-8-thia-dibe...)
Affinity DataKi:  15nMAssay Description:Inhibition of [125I]iodosulpiride binding to human Dopamine receptor D3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162959((11-Fluoro-2,3,3a,12b-tetrahydro-1-oxa-8-thia-dibe...)
Affinity DataKi:  22nMAssay Description:Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162959((11-Fluoro-2,3,3a,12b-tetrahydro-1-oxa-8-thia-dibe...)
Affinity DataKi:  40nMAssay Description:Inhibition of [3H]nisoxetine binding to rat Norepinephrine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162959((11-Fluoro-2,3,3a,12b-tetrahydro-1-oxa-8-thia-dibe...)
Affinity DataKi:  93nMAssay Description:Inhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162959((11-Fluoro-2,3,3a,12b-tetrahydro-1-oxa-8-thia-dibe...)
Affinity DataKi:  156nMAssay Description:Inhibition of [3H]rauwolscine binding to Alpha-2A adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed