BDBM50162992 3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(1-isoquinolin-4-yl-1H-indol-3-yl)-pyrrole-2,5-dione::CHEMBL359808

SMILES CN(C)CCCn1nc(C2=C(C(=O)NC2=O)c2cn(-c3cncc4ccccc34)c3ccccc23)c2ccccc12

InChI Key InChIKey=LMIPLKOPDQGFNB-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50162992   

TargetProtein kinase C beta type(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162992(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human Protein kinase C beta 2 using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162992(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50: 290nMAssay Description:Inhibition of human Protein kinase C alpha using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162992(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50: 86nMAssay Description:Inhibition of IL-8 release by HEK293 cells expressing PKC-beta2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162992(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50: 92nMAssay Description:Inhibition of human Protein kinase C beta 1 using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162992(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of rabbit Glycogen synthase kinase-3 betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162992(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50: 250nMAssay Description:Inhibition of human Protein kinase C gamma using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162992(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataKi:  490nMAssay Description:Inhibition of Potassium channel HERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed