BDBM50162993 3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(1-pyridin-3-yl-1H-indol-3-yl)-pyrrole-2,5-dione::CHEMBL368416

SMILES CN(C)CCCn1nc(C2=C(C(=O)NC2=O)c2cn(-c3cccnc3)c3ccccc23)c2ccccc12

InChI Key InChIKey=DNPFEENAAKLCMC-UHFFFAOYSA-N

Data  1 KI  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50162993   

TargetProtein kinase C alpha type(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162993(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50: 120nMAssay Description:Inhibition of human Protein kinase C alpha using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162993(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human Protein kinase C beta 2 using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162993(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of Platelet-derived growth factor receptor in P19 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162993(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human Protein kinase C beta 1 using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin receptor(Mouse)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162993(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Insulin receptor kinase in P19 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162993(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50: 150nMAssay Description:Inhibition of rabbit Glycogen synthase kinase-3 betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162993(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50: 210nMAssay Description:Inhibition of human Protein kinase C gamma using [gamma-33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162993(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50: 82nMAssay Description:Inhibition of IL-8 release by HEK293 cells expressing PKC-beta2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C delta type(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162993(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50: 250nMAssay Description:Inhibition of Protein kinase C deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Mouse)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162993(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50: 310nMAssay Description:Inhibition of Cyclin-dependent kinase 1 in P19 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C zeta type(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162993(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of Protein kinase C zetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Mouse)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162993(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Mitogen-activated protein kinase/extracellular signal-regulated kinase 2 in P19 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Mouse)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162993(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Epidermal growth factor receptor in P19 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162993(3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...)
Affinity DataKi:  610nMAssay Description:Inhibition of Potassium channel HERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed