BDBM50163221 4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (4-trifluoromethyl-phenyl)-amide::CHEMBL179739

SMILES FC(F)(F)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2C(F)(F)F)cc1

InChI Key InChIKey=FADBMGBZPIJMIQ-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50163221   

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50163221(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of PMA-activated human TRPV1 receptor in [Ca2+] influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50163221(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of anandamide activated human TRPV1 receptor in [Ca2+] influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50163221(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of anandamide activated human TRPV1 receptor in [Ca2+] influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50163221(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of acid activated rat TRPV1 receptor in [Ca2+] influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50163221(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)
Affinity DataIC50: 5nMAssay Description:In vitro inhibition of anandamide activated human TRPV1 receptor in [Ca2+] influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50163221(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]resiniferatoxin from human Transient receptor potential vanilloid 1 receptor; (n=2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50163221(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)
Affinity DataIC50: 57nMAssay Description:Inhibition of human transient receptor potential vanilloid 1 receptor (n=6)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50163221(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)
Affinity DataIC50: 90nMAssay Description:Inhibition of rat transient receptor potential vanilloid 1 receptor (n=4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed