BDBM50164232 6-(2-(2,6-difluorophenyl)-4-phenyl-1H-imidazol-5-yl)-1-(isopropylsulfonyl)-1H-benzo[d]imidazol-2-amine::6-[2-(2,6-Difluoro-phenyl)-5-phenyl-3H-imidazol-4-yl]-1-(propane-2-sulfonyl)-1H-benzoimidazol-2-ylamine::CHEMBL364572

SMILES CC(C)S(=O)(=O)n1c(N)nc2ccc(cc12)-c1[nH]c(nc1-c1ccccc1)-c1c(F)cccc1F

InChI Key InChIKey=NQPPPAJKEZYMMP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50164232   

TargetCytochrome P450 3A4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50164232(6-[2-(2,6-Difluoro-phenyl)-5-phenyl-3H-imidazol-4-...)
Affinity DataIC50: 6.30nMAssay Description:In vitro inhibitory concentration against Cytochrome P450 3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50164232(6-[2-(2,6-Difluoro-phenyl)-5-phenyl-3H-imidazol-4-...)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50164232(6-[2-(2,6-Difluoro-phenyl)-5-phenyl-3H-imidazol-4-...)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human recombinant p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50164232(6-[2-(2,6-Difluoro-phenyl)-5-phenyl-3H-imidazol-4-...)
Affinity DataIC50: 45.7nMAssay Description:Inhibition of mouse p38alpha in anisomycin-stimulated RAW 264.7 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed