BDBM50168944 CHEMBL3805885

SMILES COC(=O)Cn1cc(COC[C@H](NC(=O)[C@H](Cc2cccc(Br)c2)NC(=O)c2ccc(cc2)-c2ccccc2)C#N)nn1

InChI Key InChIKey=ANZFZARZEQENJQ-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50168944   

TargetCathepsin B(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50168944(CHEMBL3805885)
Affinity DataKi:  26nMpH: 6.0Assay Description:Inhibition of human liver cathepsin B using Cbz-Arg-Arg-pNA as substrate at pH 6 incubated for 30 mins measured for 20 mins by photometrical analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details Article
PubMed
TargetCathepsin K(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50168944(CHEMBL3805885)
Affinity DataKi:  68nMAssay Description:Inhibition of human recombinant cathepsin K using Cbz-Leu-Arg-AMC as substrate incubated for 30 mins measured for 20 mins by spectrofluorometrical an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details Article
PubMed
TargetCathepsin B(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50168944(CHEMBL3805885)
Affinity DataKi:  131nMpH: 4.5Assay Description:Inhibition of human liver cathepsin B using Abz-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH as substrate at pH 4.5 incubated for 30 mins measured for 10 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details Article
PubMed
TargetCathepsin B(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50168944(CHEMBL3805885)
Affinity DataKi:  136nMpH: 4.5Assay Description:Inhibition of human liver cathepsin B using Cbz-Arg-Arg-pNA as substrate at pH 4.5 incubated for 30 mins measured for 20 mins by photometrical analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details Article
PubMed
TargetCathepsin S(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50168944(CHEMBL3805885)
Affinity DataKi:  186nMAssay Description:Inhibition of human recombinant cathepsin S using Cbz-Phe-Arg-AMC as substrate incubated for 60 mins measured for 20 mins by spectrofluorometrical an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details Article
PubMed
TargetProcathepsin L(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50168944(CHEMBL3805885)
Affinity DataKi:  431nMAssay Description:Inhibition of human liver cathepsin L using Cbz-Phe-Arg-pNA as substrate incubated for 30 mins measured for 20 mins by photometrical analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details Article
PubMed