BDBM50171958 CHEMBL3806172::US10106508, Compound I-16

SMILES CCOC(C)Oc1cc2ncnc(Nc3ccc(F)c(c3)[N+]([O-])=O)c2c2OCCOc12

InChI Key InChIKey=KPOWUQIMHGWQLY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50171958   

TargetEpidermal growth factor receptor(Human)
Beijing University of Technology

Curated by ChEMBL
LigandPNGBDBM50171958(CHEMBL3806172 | US10106508, Compound I-16)
Affinity DataIC50: 232nMAssay Description:Inhibition of wild type EGFR (unknown origin) autophosphorylation preincubated for 30 mins followed by ATP addition measured after 1 hr by kinase-glo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Beijing University of Technology

Curated by ChEMBL
LigandPNGBDBM50171958(CHEMBL3806172 | US10106508, Compound I-16)
Affinity DataIC50: 271nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) autophosphorylation preincubated for 30 mins followed by ATP addition measured after 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Beijing University of Technology

Curated by ChEMBL
LigandPNGBDBM50171958(CHEMBL3806172 | US10106508, Compound I-16)
Affinity DataIC50: 300nMAssay Description:The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM50171958(CHEMBL3806172 | US10106508, Compound I-16)
Affinity DataIC50: 300nMAssay Description:The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent