BDBM50172040 2-Hydroxy-2,4-dimethyl-4-phenyl-pentanoic acid (1-oxo-1,3-dihydro-isobenzofuran-5-yl)-amide::CHEMBL195021

SMILES CC(O)(CC(C)(C)c1ccccc1)C(=O)Nc1ccc2C(=O)OCc2c1

InChI Key InChIKey=YGYIVBNMBYBQGZ-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50172040   

TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50172040(2-Hydroxy-2,4-dimethyl-4-phenyl-pentanoic acid (1-...)
Affinity DataEC50:  2.37E+3nMAssay Description:Effective concentration against inhibition of Dexamethasone induced glucocorticoid receptor transactivation of mouse mammary tumor virus luciferase g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50172040(2-Hydroxy-2,4-dimethyl-4-phenyl-pentanoic acid (1-...)
Affinity DataIC50: 370nMAssay Description:Binding affinity towards glucocorticoid receptor using fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50172040(2-Hydroxy-2,4-dimethyl-4-phenyl-pentanoic acid (1-...)
Affinity DataIC50: 60nMAssay Description:Binding affinity towards mineralocorticoid receptor using fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50172040(2-Hydroxy-2,4-dimethyl-4-phenyl-pentanoic acid (1-...)
Affinity DataIC50: 85nMAssay Description:Binding affinity towards progesterone receptor using fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed