BDBM50172242 CHEMBL3809081

SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cncnn2)s1)c1ccc(F)c(OC)c1

InChI Key InChIKey=KRSPFSSFLXKAOW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50172242   

TargetGlutaminase kidney isoform, mitochondrial(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50172242(CHEMBL3809081)
Affinity DataIC50: 5nMAssay Description:Inhibition of GLS1 in human PC3 cells assessed as cellular glutamate depletion levels after 6 hrs by Glutamate Oxidase/ AmplexRed coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details Article
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50172242(CHEMBL3809081)
Affinity DataIC50: 71nMAssay Description:Inhibition of 6His-tagged GLS1 (63-669 residues) (unknown origin) expressed in Escherichia coli using glutamine as substrate after 15 mins by Glutama...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details Article
PubMed