BDBM50173698 CHEMBL372340::[5-(3-Bromo-phenyl)-pyridazin-3-yl]-isopropyl-amine

SMILES CC(C)Nc1cc(cnn1)-c1cccc(Br)c1

InChI Key InChIKey=UMNMVUGGTKAKKC-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50173698   

TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50173698([5-(3-Bromo-phenyl)-pyridazin-3-yl]-isopropyl-amin...)
Affinity DataKi:  7.20nMpH: 7.4Assay Description:Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2 expressed in mouse fibrobla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50173698([5-(3-Bromo-phenyl)-pyridazin-3-yl]-isopropyl-amin...)
Affinity DataKi:  7.30nMpH: 7.4Assay Description:Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric acid A receptor alpha-1-beta-3-gamma-2 expressed in mouse fibrobla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50173698([5-(3-Bromo-phenyl)-pyridazin-3-yl]-isopropyl-amin...)
Affinity DataKi:  22nMpH: 7.4Assay Description:Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric acid A receptor alpha-3-beta-3-gamma-2 expressed in mouse fibrobla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed