BDBM50174835 4'-(4-toluenesulfonamido)-4-hydroxychalcone::4'-(p-Toluenesulfonamide)-4-hydroxychalcone::CHEMBL371723::N-(4-(3-(4-hydroxyphenyl)acryloyl)phenyl)-4-methylbenzenesulfonamide::Sulfonamide chalcone, 4

SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)C(=O)\C=C\c1ccc(O)cc1

InChI Key InChIKey=KDODYFOOJCIHGK-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50174835   

TargetTrans-sialidase(Trypanosoma cruzi)
University of British Columbia

LigandPNGBDBM50174835(CHEMBL371723 | 4'-(4-toluenesulfonamido)-4-hydroxy...)
Affinity DataIC50: 7.30E+4nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using trans-sialidase, a membrane-associated protein.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2012
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Department of Functional Crop

Curated by ChEMBL
LigandPNGBDBM50174835(CHEMBL371723 | 4'-(4-toluenesulfonamido)-4-hydroxy...)
Affinity DataIC50: 2.33E+4nMAssay Description:Inhibition of monophenolase activity of mushroom tyrosinase using as L-tyrosine substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetBeta-amylase(Barley)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50174835(CHEMBL371723 | 4'-(4-toluenesulfonamido)-4-hydroxy...)
Affinity DataIC50: 2.47E+5nMAssay Description:Inhibitory activity against barley beta amylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetAlpha-amylase(Bacillus licheniformis)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50174835(CHEMBL371723 | 4'-(4-toluenesulfonamido)-4-hydroxy...)
Affinity DataIC50: 8.78E+4nMAssay Description:Inhibitory activity against Bacillus licheniformis alpha amylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 10(Rat)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50174835(CHEMBL371723 | 4'-(4-toluenesulfonamido)-4-hydroxy...)
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibition of rat TREK2 channel -mediated current expressed in HEK293 at 60 mV holding potential by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Bovine)
Shiv Nadar University

Curated by ChEMBL
LigandPNGBDBM50174835(CHEMBL371723 | 4'-(4-toluenesulfonamido)-4-hydroxy...)
Affinity DataIC50: 9.10E+4nMAssay Description:Inhibition of bovine kidney alpha-fucosidase using PNPG as substrate incubated for 10 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAlpha-mannosidase(Jack bean)
Shiv Nadar University

Curated by ChEMBL
LigandPNGBDBM50174835(CHEMBL371723 | 4'-(4-toluenesulfonamido)-4-hydroxy...)
Affinity DataIC50: 1.05E+5nMAssay Description:Inhibition of jack bean alpha-mannosidase using PNPG as substrate incubated for 10 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Department of Functional Crop

Curated by ChEMBL
LigandPNGBDBM50174835(CHEMBL371723 | 4'-(4-toluenesulfonamido)-4-hydroxy...)
Affinity DataKi:  1.26E+4nMAssay Description:Competitive inhibition of monophenolase activity of mushroom tyrosinase using as L-tyrosine substrate by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed