BDBM50174837 4'-(p-toluenesulfonamide)-3,4-dihydroxy chalcone::CHEMBL199829::Sulfonamide chalcone, 5

SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)C(=O)\C=C\c1ccc(O)c(O)c1

InChI Key InChIKey=XCEAUELSIXURQB-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50174837   

TargetAlpha-amylase(Bacillus licheniformis)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50174837(CHEMBL199829 | Sulfonamide chalcone, 5 | 4'-(p-tol...)
Affinity DataIC50: 1.94E+5nMAssay Description:Inhibitory activity against Bacillus licheniformis alpha amylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetBeta-amylase(Barley)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50174837(CHEMBL199829 | Sulfonamide chalcone, 5 | 4'-(p-tol...)
Affinity DataIC50: 6.50E+4nMAssay Description:Inhibitory activity against barley beta amylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50174837(CHEMBL199829 | Sulfonamide chalcone, 5 | 4'-(p-tol...)
Affinity DataIC50: 900nMAssay Description:Inhibition of Trypanosoma cruzi trans-sialidase using CF3MuSA as substrate by UV/visible spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Bovine)
Shiv Nadar University

Curated by ChEMBL
LigandPNGBDBM50174837(CHEMBL199829 | Sulfonamide chalcone, 5 | 4'-(p-tol...)
Affinity DataIC50: 9.10E+4nMAssay Description:Inhibition of bovine kidney alpha-fucosidase using PNPG as substrate incubated for 10 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAlpha-mannosidase(Jack bean)
Shiv Nadar University

Curated by ChEMBL
LigandPNGBDBM50174837(CHEMBL199829 | Sulfonamide chalcone, 5 | 4'-(p-tol...)
Affinity DataIC50: 1.05E+5nMAssay Description:Inhibition of jack bean alpha-mannosidase using PNPG as substrate incubated for 10 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University of British Columbia

LigandPNGBDBM50174837(CHEMBL199829 | Sulfonamide chalcone, 5 | 4'-(p-tol...)
Affinity DataKi:  4.60E+3nM ΔG°:  -7.52kcal/mole IC50: 900nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using trans-sialidase, a membrane-associated protein.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2012
Entry Details Article
PubMed