BDBM50177592 (5,11-dihydro-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)-[4-(3-methyl-pyrazol-1-yl)-2-trifluoromethyl-phenyl]-methanone::CHEMBL201889

SMILES Cc1ccn(n1)-c1ccc(C(=O)N2Cc3cccnc3Nc3ccccc23)c(c1)C(F)(F)F

InChI Key InChIKey=FOMNYBUNFIUPHX-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50177592   

TargetVasopressin V1a receptor(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177592((5,11-dihydro-benzo[b]pyrido[2,3-e][1,4]diazepin-6...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonism of AVP-induced response at V1a receptor in isolated rat tail arteriesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177592((5,11-dihydro-benzo[b]pyrido[2,3-e][1,4]diazepin-6...)
Affinity DataIC50: 5.95E+3nMAssay Description:Displacement of [3H]AVP from human V1a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetVasopressin V2 receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177592((5,11-dihydro-benzo[b]pyrido[2,3-e][1,4]diazepin-6...)
Affinity DataIC50: 493nMAssay Description:Displacement of [3H]AVP from human V2 receptor transfected in LV2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetOxytocin receptor(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177592((5,11-dihydro-benzo[b]pyrido[2,3-e][1,4]diazepin-6...)
Affinity DataIC50: 1.26E+3nMAssay Description:Antagonism of OT-induced response at OT receptor in rat uterine stripsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetVasopressin V2 receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177592((5,11-dihydro-benzo[b]pyrido[2,3-e][1,4]diazepin-6...)
Affinity DataEC50:  1.67nMAssay Description:Binding to human V2 receptor expressed in LV2 cells by cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed