BDBM50177664 CHEMBL3814414

SMILES Cc1nc(N)ncc1-c1nc(N2CCOCC2)c2nc3n(CCOC3(C)C)c2n1

InChI Key InChIKey=BOVRFNAULGLSIP-UHFFFAOYSA-N

Data  2 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50177664   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Genentech

Curated by ChEMBL

LigandBDBM50177664(CHEMBL3814414)Copy SMILESCopy InChI

Affinity DataKi:  2nMAssay Description:Inhibition of recombinant PI3Kalpha (unknown origin) using dioctanoylglycerol-PIP2 as substrate incubated for 30 mins in presence of TAMRA-PIP3 by fl...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/16/2017
Entry Details Article
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TargetSerine/threonine-protein kinase mTOR(Human)
Genentech

Curated by ChEMBL

LigandBDBM50177664(CHEMBL3814414)Copy SMILESCopy InChI

Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of human recombinant mTOR (1360 to 2549 residues) expressed in insect cells assessed as inhibition of GFP-labeled 4-EBP1 phosphorylation a...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/16/2017
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL