BDBM50177835 2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl]amino}-5-(prop-2-yn-1-yloxy)benzo-1,4-quinone::CHEMBL198744

SMILES COc1cc2c(N=C3CC(=O)C(OCC#C)=CC3=O)ncnc2cc1OCCCN1CCCC1

InChI Key InChIKey=UPQQZTMIRXWKNI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50177835   

TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177835(2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177835(2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177835(2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...)
Affinity DataIC50: 9nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathioneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed