BDBM50178276 5-(2-(2-cyclopropoxy-5-(trifluoromethoxy)benzylamino)-1-phenyl-8-aza-bicyclo[3.2.1]octan-6-yl)-2H-1,2,4-triazol-3(4H)-one::CHEMBL379010

SMILES O=c1[nH]nc(C2CC3(c4ccccc4)NC2CCC3NCc2cc(OC(F)(F)F)ccc2OC2CC2)[nH]1

InChI Key InChIKey=QKMNCMIKEOYLQG-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50178276   

TargetSubstance-P receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178276BDBM50178276(5-(2-(2-cyclopropoxy-5-(trifluoromethoxy)benzylami...)
Affinity DataIC50: 0.610nMAssay Description:Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178276BDBM50178276(5-(2-(2-cyclopropoxy-5-(trifluoromethoxy)benzylami...)
Affinity DataKi:  5.80E+3nMAssay Description:Displacement of [35S]-labeled MK499 from cloned hERG potassium channel expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed