BDBM50178591 2-((4-(5-fluoro-1H-indol-3-yl)-5,6-dihydropyridin-1(2H)-yl)methyl)-8-methoxy-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine::CHEMBL203018

SMILES COc1cccc2N(C)CC(CN3CCC(=CC3)c3c[nH]c4ccc(F)cc34)Oc12

InChI Key InChIKey=MEZAIHGIIAYINU-UHFFFAOYSA-N

Data  2 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50178591   

Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50178591(2-((4-(5-fluoro-1H-indol-3-yl)-5,6-dihydropyridin-...)
Affinity DataEC50:  190nMAssay Description:Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50178591(2-((4-(5-fluoro-1H-indol-3-yl)-5,6-dihydropyridin-...)
Affinity DataKi:  12.6nMAssay Description:Displacement of [3H]paroxetine from rat cortical 5-HT reuptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50178591(2-((4-(5-fluoro-1H-indol-3-yl)-5,6-dihydropyridin-...)
Affinity DataKi:  140nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed