BDBM50182221 CHEMBL381366::N-((R)-6-((tert-butylamino)methyl)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-((S)-1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)acetamide

SMILES CC(C)(C)NCc1ccc2[C@@H](CCCc2c1)NC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1cccc(c1)C(F)(F)F

InChI Key InChIKey=BFWDXOBUPPVYOP-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50182221   

TargetB1 bradykinin receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50182221(N-((R)-6-((tert-butylamino)methyl)-1,2,3,4-tetrahy...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human B1 receptor by calcium influx functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50182221(N-((R)-6-((tert-butylamino)methyl)-1,2,3,4-tetrahy...)
Affinity DataIC50: 23nMAssay Description:Inhibition of human B1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50182221(N-((R)-6-((tert-butylamino)methyl)-1,2,3,4-tetrahy...)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50182221(N-((R)-6-((tert-butylamino)methyl)-1,2,3,4-tetrahy...)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50182221(N-((R)-6-((tert-butylamino)methyl)-1,2,3,4-tetrahy...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50182221(N-((R)-6-((tert-butylamino)methyl)-1,2,3,4-tetrahy...)
Affinity DataKi:  23nMAssay Description:Antagonist activity at human bradykinin B1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed