BDBM50184466 CHEMBL3823659

SMILES CC(=O)N1CCC(CC1)n1cc(Nc2ncc(Cl)c(n2)-c2cnc3ccccn23)cn1

InChI Key InChIKey=FBFCEASGGVTKEY-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50184466   

TargetCyclin-dependent kinase 7(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50184466(CHEMBL3823659)
Affinity DataIC50: 21nMAssay Description:Inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2017
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50184466(CHEMBL3823659)
Affinity DataIC50: 25nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2017
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50184466(CHEMBL3823659)
Affinity DataIC50: 37nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2017
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50184466(CHEMBL3823659)
Affinity DataIC50: 42nMAssay Description:Inhibition of recombinant human IGF-1R using fluorescent labeled FL-KKSRGDYMTMQIG-CONH2 as substrate after 1 hr 50 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2017
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50184466(CHEMBL3823659)
Affinity DataIC50: 42nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2017
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50184466(CHEMBL3823659)
Affinity DataIC50: 66nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2017
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50184466(CHEMBL3823659)
Affinity DataIC50: 181nMAssay Description:Inhibition of IGF1-induced human IGF1R autophosphorylation expressed in IGF-1R knock-out mouse fibroblastsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2017
Entry Details Article
PubMed
LigandPNGBDBM50184466(CHEMBL3823659)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells after 6 mins by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2017
Entry Details Article
PubMed