BDBM50184809 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-(3-(methylsulfonyl)propoxy)pyrrolo[2,1-f][1,2,4]triazine::CHEMBL383077

SMILES Cc1cc2c(F)c(Oc3ncnn4cc(OCCCS(C)(=O)=O)c(C)c34)ccc2[nH]1

InChI Key InChIKey=DZEADOQXGYJGID-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50184809   

TargetVascular endothelial growth factor receptor 2(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184809(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)
Affinity DataIC50: 70nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184809(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against hERG by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50184809(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-6-...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibitory activity against CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed