BDBM50185722 CHEMBL3824207

SMILES CC(C)n1nc(cc1[C@H]1C[C@@](O)(C1)c1ccc(OCc2c(onc2-c2c(Cl)cccc2Cl)C2CC2)cc1Cl)C(O)=O

InChI Key InChIKey=KHTWMUPBBFFKQN-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50185722   

TargetBile acid receptor(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185722(CHEMBL3824207)
Affinity DataEC50:  9nMAssay Description:Agonist activity at GST-tagged FXR LBD (187 to 472 residues) (unknown origin) assessed as FXR interaction with b-CPSSHSSLTERHKILHRLLQEGSPS-COOH by FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185722(CHEMBL3824207)
Affinity DataEC50:  10nMAssay Description:Agonist activity at GAL4-fused N-terminal GST tagged human FXR LBD expressed in human HEK293 cells by one hybrid reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185722(CHEMBL3824207)
Affinity DataEC50: <25nMAssay Description:Agonist activity at FXR (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Phenex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185722(CHEMBL3824207)
Affinity DataEC50:  110nMAssay Description:Agonist activity at C-terminal Gal4-tagged human FXR (187 to 472 residues) expressed in HEK-293 cells co-expressing pFRluc by mammalian one hybrid as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed