BDBM50186852 4'-[1-(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-6-(pyrrolidine-1-carbonyl)-6-aza-spiro[2.5]oct-1-yl]-biphenyl-3-carbonitrile::CHEMBL208635

SMILES Fc1cc2[nH]c(nc2cc1C(F)(F)F)C1(CC11CCN(CC1)C(=O)N1CCCC1)c1ccc(cc1)-c1cccc(c1)C#N

InChI Key InChIKey=RTXJBKDZSRSMLJ-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50186852   

TargetMelanin-concentrating hormone receptor 1(Human)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50186852(4'-[1-(5-fluoro-6-trifluoromethyl-1H-benzoimidazol...)
Affinity DataIC50: 44nMAssay Description:Antagonist activity at MCHR1 (unknown origin) expressed in CHO cells co-expressing aequorin incubated for 10 mins by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50186852(4'-[1-(5-fluoro-6-trifluoromethyl-1H-benzoimidazol...)
Affinity DataKi:  44nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed