BDBM50187441 1-(5-bromo-6-chloropyridin-3-yl)-1,4-diazepane::4-(5-bromo-6-chloropyridin-3-yl)-[1,4]-diazepane::CHEMBL210742

SMILES Clc1ncc(cc1Br)N1CCCNCC1

InChI Key InChIKey=CKEZLGKKMUHEMS-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50187441   

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50187441(4-(5-bromo-6-chloropyridin-3-yl)-[1,4]-diazepane |...)
Affinity DataIC50: 1.41nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50187441(4-(5-bromo-6-chloropyridin-3-yl)-[1,4]-diazepane |...)
Affinity DataEC50:  57.5nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in HEK293 cells assessed as intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50187441(4-(5-bromo-6-chloropyridin-3-yl)-[1,4]-diazepane |...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of [3H]cytisine binding to alpha4beta2 nACHR in Wistar rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed