BDBM50187791 4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxy-1-(3-methoxypropanoyl)piperidine-4-carboxamide::CHEMBL377272

SMILES COCCC(=O)N1CCC(CS(=O)(=O)c2ccc(OCC#CC)cc2)(CC1)C(=O)NO

InChI Key InChIKey=LIJQQAFTSYEDRO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50187791   

TargetMatrix metalloproteinase-14(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187791(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydr...)
Affinity DataIC50: 891nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50187791(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydr...)
Affinity DataIC50: 6nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187791(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydr...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187791(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydr...)
Affinity DataIC50: 13nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187791(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydr...)
Affinity DataIC50: 24nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed