BDBM50187952 CHEMBL209650::rac-methyl 9a-ethyl-7-oxo-3,7,8,9,9a,10-hexahydroindeno[2,1-e]indazole-6-carboxylate

SMILES CCC12Cc3c(ccc4[nH]ncc34)C1=C(C(=O)OC)C(=O)CC2

InChI Key InChIKey=MEWRVCQMJAABQU-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50187952   

TargetEstrogen receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187952(rac-methyl 9a-ethyl-7-oxo-3,7,8,9,9a,10-hexahydroi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to human ERalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187952(rac-methyl 9a-ethyl-7-oxo-3,7,8,9,9a,10-hexahydroi...)
Affinity DataEC50:  1.17E+3nMAssay Description:Agonist activity at human ERalpha transfected in HEK293 cells assessed as transactivation of alkaline phosphatase reporter geneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187952(rac-methyl 9a-ethyl-7-oxo-3,7,8,9,9a,10-hexahydroi...)
Affinity DataEC50:  210nMAssay Description:Agonist activity at human ERbeta transfected in HEK293 cells assessed as transactivation of alkaline phosphatase reporter geneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187952(rac-methyl 9a-ethyl-7-oxo-3,7,8,9,9a,10-hexahydroi...)
Affinity DataIC50: 207nMAssay Description:Binding affinity to human ERbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed