BDBM50188098 (R)-1-(2-(2-ethoxyphenyl)-1-phenylethyl)piperazine hydrochloride::CHEMBL403441::CHEMBL534723

SMILES CCOc1ccccc1C[C@@H](N1CCNCC1)c1ccccc1

InChI Key InChIKey=CVFBVSUFNWOPLD-UHFFFAOYSA-N

Data  3 KI  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50188098   

TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataIC50: 13nMAssay Description:Inhibition of [3H]5HT uptake at human 5HT transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataIC50: 13nMAssay Description:Inhibition of [3H]5-HT reuptake at 5HT transporter in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataIC50: 14nMAssay Description:Inhibition of [3H]5-HT uptake at human recombinant 5HT transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataIC50: 16nMAssay Description:Inhibition of [3H]NA uptake at human NA transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataIC50: 16nMAssay Description:Inhibition of [3H]NA reuptake at NA transporter in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataIC50: 18nMAssay Description:Inhibition of [3H]NA uptake at human recombinant NA transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataIC50: 400nMAssay Description:Inhibition of [3H]dopamine uptake at human dopamine transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataKi:  2.65E+3nMAssay Description:Displacement of [3H]dopamine from human DAT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of [3H]DA uptake at human recombinant DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of [3H]DA reuptake at DA transporter in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataIC50: 6.95E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataIC50: 1.60E+4nMAssay Description:Binding affinity to hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188098(CHEMBL534723 | CHEMBL403441 | (R)-1-(2-(2-ethoxyph...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed