BDBM50189952 CHEMBL3827948::US10618914, Compound 19::US11111253, Compound UPCDC10263

SMILES CC1Sc2nnc(-c3[nH]nc4CCCc34)n2N=C1c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=FXYPPPBQIAYYJT-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50189952   

TargetSignal transducer and activator of transcription 3(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50189952(CHEMBL3827948 | US10618914, Compound 19 | US111112...)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of IL6-induced STAT3 in human CAL33 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2017
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 1-alpha/beta(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50189952(CHEMBL3827948 | US10618914, Compound 19 | US111112...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of IFNgamma-induced STAT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2017
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50189952(CHEMBL3827948 | US10618914, Compound 19 | US111112...)
Affinity DataIC50: 8.20E+3nMAssay Description:Compound samples (in 3-5 mg quantities) were evaluated in a variety of assays. All compound submissions were fully characterized (1H, 13C, IR, HRMS),...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetSignal transducer and activator of transcription 1-alpha/beta(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50189952(CHEMBL3827948 | US10618914, Compound 19 | US111112...)
Affinity DataIC50: 5.00E+4nMAssay Description:Compound samples (in 3-5 mg quantities) were evaluated in a variety of assays. All compound submissions were fully characterized (1H, 13C, IR, HRMS),...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetSignal transducer and activator of transcription 3(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50189952(CHEMBL3827948 | US10618914, Compound 19 | US111112...)
Affinity DataIC50: 8.50E+3nMAssay Description:Compound samples (in 3-5 mg quantities) were evaluated in a variety of assays. All compound submissions were fully characterized (1H, 13C, IR, FIRMS)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2022
Entry Details
Go to US Patent