BDBM50190783 CHEMBL379302::N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-6-carboxamide

SMILES O=C(N[C@H]1CN2CCC1CC2)c1ccc2ccoc2c1

InChI Key InChIKey=LGWFAAILRNJWJB-UHFFFAOYSA-N

Data  5 KI  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50190783   

LigandPNGBDBM50190783(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-...)
Affinity DataEC50:  86nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Targacept

Curated by ChEMBL
LigandPNGBDBM50190783(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-...)
Affinity DataIC50: 962nMAssay Description:Inhibition of 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190783(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50190783(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-...)
Affinity DataIC50: 8.10E+4nMAssay Description:Inhibition of alpha-3-beta-4 nAChR expressed in SHSY5Y cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50190783(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of alpha-1-beta-1-gamma-delta nAChR expressed in TE671cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50190783(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-...)
Affinity DataKi:  12.5nMAssay Description:Binding affinity to alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50190783(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-...)
Affinity DataKi:  12.5nMAssay Description:Displacement of [3H]MLA from alpha-7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Targacept

Curated by ChEMBL
LigandPNGBDBM50190783(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-...)
Affinity DataKi:  310nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50190783(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-...)
Affinity DataKi:  310nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50190783(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-...)
Affinity DataKi:  962nMAssay Description:Activity at 5HT3 receptor expressed in SHEP1 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed