BDBM50192665 CHEMBL3892579

SMILES Fc1ccc(NC(=O)N2N=C(CC2c2ccc(F)cc2)c2ccncc2)cc1

InChI Key InChIKey=RDQXNTXNNZITKD-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50192665   

TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192665(CHEMBL3892579)
Affinity DataIC50: 29nMAssay Description:Inhibition of T-type calcium channel Cav3.1 (unknown origin) expressed in HEK293 cells assessed as calcium influx by Fluo-4-AM dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192665(CHEMBL3892579)
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant T-type calcium channel Cav3.2 (unknown origin) expressed in HEK293 cells assessed as inhibition of CaCl2-induced calcium in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192665(CHEMBL3892579)
Affinity DataIC50: 220nMAssay Description:Inhibition of human T-type calcium channel Cav3.2 expressed in CHO cells assessed as inhibition of calcium tail current at -60 mV holding potential m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192665(CHEMBL3892579)
Affinity DataIC50: 340nMAssay Description:Inhibition of T-type calcium channel Cav3.3 (unknown origin) expressed in HEK293 cells assessed as calcium influx by Fluo-4-AM dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192665(CHEMBL3892579)
Affinity DataIC50: 450nMAssay Description:Inhibition of human T-type calcium channel Cav3.1 expressed in CHO cells assessed as inhibition of calcium tail current at -60 mV holding potential m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192665(CHEMBL3892579)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human T-type calcium channel Cav3.2 expressed in CHO cells assessed as inhibition of calcium tail current at -90 mV holding potential m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192665(CHEMBL3892579)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human T-type calcium channel Cav3.1 expressed in CHO cells assessed as inhibition of calcium tail current at -90 mV holding potential m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2018
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192665(CHEMBL3892579)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using testosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2018
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192665(CHEMBL3892579)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192665(CHEMBL3892579)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human T-type calcium channel Cav3.3 expressed in CHO cells assessed as inhibition of calcium tail current at -60 mV holding potential m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2018
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192665(CHEMBL3892579)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of recombinant T-type calcium channel Cav1.2 (unknown origin) expressed in HEK293 cells assessed as inhibition of Kcl-induced calcium infl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2018
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192665(CHEMBL3892579)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human T-type calcium channel Cav3.3 expressed in CHO cells assessed as inhibition of calcium tail current at -90 mV holding potential m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2018
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192665(CHEMBL3892579)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2018
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192665(CHEMBL3892579)
Affinity DataIC50: 4.40E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2018
Entry Details Article
PubMed