BDBM50192784 (S)-1-(4-(2-fluoroethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione::(S)-1-(4-(2-fluoroethoxy)benzyl)-5-[1-(2-phenoxymethylpyrrolidinyl)sulfonyl]isatin::1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione::CHEMBL213759

SMILES FCCOc1ccc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N2CCC[C@H]2COc2ccccc2)cc1

InChI Key InChIKey=JVKBLHAUEXSZHN-UHFFFAOYSA-N

Data  1 KI  16 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50192784   

TargetCaspase-3(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50192784(1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-p...)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50192784(1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-p...)
Affinity DataIC50: 9.77nMAssay Description:Inhibition of caspase3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50192784(1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-p...)
Affinity DataEC50:  4.50E+3nMAssay Description:Inhibition of staurosporine induced activation of caspase 3 activation in human Hela cells assessed as hydrolysis of Z-DEVD-R110 substrate by micropl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCaspase-7(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50192784(1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-p...)
Affinity DataIC50: 23.5nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50192784(1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-p...)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-8(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50192784(1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-p...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant caspase 8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-6(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50192784(1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-p...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human recombinant caspase 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50192784(1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-p...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-7(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50192784(1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-p...)
Affinity DataIC50: 22.4nMAssay Description:Inhibition of caspase 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-6(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50192784(1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-p...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of caspase 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50192784(1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-p...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of caspase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50192784(1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-p...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of caspase 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-8(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50192784(1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-p...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of caspase 8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50192784(1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-p...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-8(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50192784(1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-p...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant caspase 8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-7(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50192784(1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-p...)
Affinity DataIC50: 23.5nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-6(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50192784(1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-p...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human recombinant caspase 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCaspase-3(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50192784(1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-p...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to human caspase 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed